I recently had a miscarriage and it was determind that the baby had Turner Syndrome. My FS has suggested that we do PGD testing witht he next IVF cyle. However, I have read that PGD can harm the embryos. I am only 29 and do not have any genetic disorders. In your opinion, can PGD harm embryos or is it worth doing?Monday, August 18th, 2008
You were very unfortunate to have a Turner syndrome pregnancy. This is very rare with an incidence of 1:2500 pregnancies. The chance of recurrence in subsequent pregnancies is extremely low and does not warrant PGD. PGD does not exclude Turner syndrome as there might be more than one cell line in the embryo (mosaism) and as only a maximum of 2 cells can be analysed per embryo, it is still possible to miss the Turner syndrome. Another aspect is the fact that biopsied embryos tend to have a lower implantation rate than non biopsied embryos.(17% vs. 23%) Therefore, in view of your age, the fact that the recurrence rate is almost zero and the fact that PGD is not 100% accurate, I can see no reason to do PGD in your case.
- Week 19 answers kindly provided by Dr. Stephan Volschenk -