Archive for March, 2009

What “characteristics” does the lab look at when identifying the best embryo to place back?

Thursday, March 26th, 2009

Generally the following:

-          Normal fertilization

-          The rate at which they develop

-          Where they are from a development point of view on either day3 or 5 ( Cell number or morphology depending whether day 3 or 5)

-          The percentage of fragmentation within the embryo

-     The thickness of the Zonb Pellucida (“shell”)

- Week 32 answers kindly provided by Dr. Stephan Volschenk -

What is your opinion about DHEA for ladies with high FSH and low AMH?

Thursday, March 26th, 2009

DHEA is still very controversial. A few years ago a few very small powered studies were published on the matter. None were prospective though and it had kind of “fallen by the wayside” Recently new interest has been shown in the matter, especially in the U.S. Large randomized studies are however needed on the matter in order to determine whether it does make a difference or not. It might have no benefit at all for all we know. The side effect profile, if taken with supervision, is very low and therefore some institutions are of the feeling that one has nothing to loose in taking it now or at least until we have more evidence as to its effect.

- Week 32 answers kindly provided by Dr. Stephan Volschenk -

I had the Ovidrel trigger on day 7 of my cycle and my cycles are normally between 25 and 27 days long . I have been asked to contact my clinic if AF does not begin after 14 days which would mean a 22 day cycle? Does Ovidrel automatically result in a 14 day luteal phase or should my existing cycle (long luteal phase) be taken into account.

Thursday, March 26th, 2009

Ovulation generally occurs 35-44 hours post the “trigger” The luteal phase is 14 days long. However, in a small percentage of patients the egg can be released either before 35 hours or after the projected 44 hours post “trigger”. Therefore it is clear that it does not automatically leads to a 14 day luteal phase, but as a whole it generally does. (give or take a day either side)

- Week 32 answers kindly provided by Dr. Stephan Volschenk -

What is an acceptable beta post IVF? Mine was 8 and I was told to stop treatment. Other girls on the forum have had levels of 13 and one of 3 and they have continued on the treatment and there levels have done all the right things and progressed normally?

Thursday, March 26th, 2009

This depends entirely on how long after the embryo transfer this is done. A reassuring level 14 days post ET is usually in the vicinity of  about 100.

- Week 32 answers kindly provided by Dr. Stephan Volschenk -

I was diagnosed with stage 1B1 cervical cancer and had a radical trachelectomy in September 2008, which was successful. An abdominal cerclage was placed at the same time. We have been advised that it will be difficult for me to conceive because of the absence of the cervix and cervical mucous. Unfortunately, our attempts at AI have also been unsuccessful because the cervical os is too tight to allow a catheter through, although it is sufficient to allow menstrual blood through. The surgeon who performed the trachelectomy told me that it ought to be possible to dilate the os, but that doing so might lead to a trade-off with the security of the cerclage. If it isn’t dilated, then ZIFT/TET is the only option really open to us, as I’ m concerned about the risk of multiples with GIFT. At this stage I’ m inclined to leave the cerclage as it is and try ZIFT/TET. However, we have not tried to conceive on our own. A post-coital test was done, which showed no sperm left alive after 2-3 hours, so we assumed that it would be best to go for fertility treatment immediately. At that stage we only really contemplated AI, and the costs of ZIFT/TET are substantially more than AI. I’ m 35 years old and neither I nor my partner have any other fertility issues. We have previously conceived without difficulty. Is it worth trying to conceive on our own or should we go straight for ZIFT/TET? Would any of the “sperm-friendly” preparations on the market in any way help to fulfil the functions of cervical mucous?

Thursday, March 26th, 2009

The issue with having had a trachelectomy from a fertility point of view is that the endocervical canal is destroyed/removed. This region is of extreme importance when it comes to natural conception. The mucus being produced in this area not only nurtures the ejaculated sperm, but also serves as a sperm reservoir, releasing sperm up into the genital tract at regular intervals. None of the “sperm friendly” preparations on the market can ever take over this function. Therefore, seeing that you are 35 years old as it is, I would encourage you to proceed directly to assisted reproduction and not waste any more time.

- Week 32 answers kindly provided by Dr. Stephan Volschenk -

Met my eerste IVB is aspirasie gedoen op dag 16 van my siklus. Daar was 15 gesonde eierselle waarvan 5 bevrug geraak het. Die siklus moes ongelukkig gekanselleer word agv ernstige OHSS. Met my tweede IVB is aspirasie gedoen op dag 12 van my siklus en is ek ingelig dat my eiersel kwaliteit baie swak was. Die embrioloog het my eierselle beskyf as “vol gate, krake en kraters en die kleur was bruin”. Geen bevrugting het plaasgevind nie. My Fertiliteitspesialis het my gekontak en gesê dat hy vermoed die aspirasie het te vroeg plaasgevind en dat die eierselle nog nie gereed was nie. Is daar enige ander rede waarom die eierselle so kan lyk en wanneer is die beste tyd vir aspirasie vir iemand soos ek wat geneig is om OHSS te ontwikkel?

Thursday, March 26th, 2009

Daar is geen verskil in die tyd wanneer aspirasie moet plaasvind tussen pasiente wat geneig is tot OHSS en die wat nie is nie. Die “trigger” vind as ‘n reel plaas wanneer die leidende 3 follikels tussen 17-18mm in deursnee is en die aspirasie volg 35 uur later.

Een moontlikheid rede vir hoe die eierselle gelyk het soos u beskryf het is eenvoudig dat die eiersel kwaliteit swak was in die betrokke siklus.

- Week 32 answers kindly provided by Dr. Stephan Volschenk -

I have alopecia areata (treated with local cortisone injection) which my Dermatologist said is probably due to Autoimmune Reasons. As I have had a previous Thyroid test and nothing was found wrong, he did not seem to think further testing necessary. When we did IVF/ICSI we transferred 2 blasotocysts, 1 hatching and were still not successful. Do you think further Auto immune testing would be advisable in my case? If so what testing should be done?

Thursday, March 26th, 2009

 

Testing for Auto Immune diseases are very difficult at the best of times. The reason is that one is not certain as to what you are testing for as the spectrums of these disorders are very wide. You therefore have to have a certain condition in mind in order to request a test that will make any sense. Screening is very unreliable for the same reason. The best we can do for now, and this is purely a shot in the dark so to speak, is to do an ANF and ACA test.

- Week 32 answers kindly provided by Dr. Stephan Volschenk -

I read about CGH embryonic screening this week (here) and would like to know whether that type of embryo genetic screening is available (or under investigation) in South Africa at all?

Thursday, March 26th, 2009

CGH ( cytogenetic comparative hybridization) is in its infancy worldwide and has only recently come to the fore. It is still very expensive due to the research phase that it is going through and has a while to go still before becoming commercially available. Due to the technical difficulties it will not be available everywhere in the world, but rather at larger dedicated centres with a dedicated genetics facility. The research is mainly being conducted in the U.K. and the U.S. and presently, and for a while still, will not be available locally.

- Week 32 answers kindly provided by Dr. Stephan Volschenk -

I have heard about reconstructive surgery for fallopian tubes? I had 2 eptopic pregnancies and would like to know if it is better to rather have IVF or reconstructive surgery? Where could I find out if I want it done? What are the costs involved?

Thursday, March 26th, 2009

The risks for ectopic pregnancy after reconstructive surgery is around 4% – 10%. Maternal age, number of children desired, coexisting infertility factors, risk for ectopic pregnancy and treatment costs are the key variables to consider when advising couples on the relative advantages and disadvantages of tubal reconstruction and IVF. IVF is the treatment of choice for older, reproductively aged woman with significant tubal diease. IVF is the preferred treatment option for women with both proximal and distal tubal disease. The extent of tubal disease and pelvic pathology are important factors in determining the prognosis for success after surgical repair.

- Week 32 answers kindly provided by Dr. Stephan Volschenk -

I have been for IUI x 2 and they say all the levels are well in the blood test for ovulation and then they say it looks good but in the end still nothing. We are using sperm donors. Am I in too big a rush to see it happen or should I consider another route?

Thursday, March 26th, 2009

There are a few important issues:

-          How old are you?

-          What is your hormone status like?

-          What is the condition of your pelvis and uterine cavity?

-          Are your fallopian tubes open?

 If all of the above are in order and you are 26 years of age, the chance of conceiving per attempt with good quality sperm is around 18% – 20%. This is cumulative over a 3-4 month time period. The older you are the less the chance per attempt.

- Week 32 answers kindly provided by Dr. Stephan Volschenk -

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