You mentioned that 60 days is the minimum period that should transpire between one IVF and the next, due to the fact that the ovaries need to recruit the next fresh cohort of antral follicles. Does this recruitment happen both on/off the BCP? Or does one need to be off the BCP for the 60 days? In other words, does down regualtion form part of this 60 day window or does down regulation still need to take place after the 60 day period? What is best practice and why? And also why do some clinics jump from one IVF to the next without the waiting period inbetween.Monday, July 21st, 2008
60 – 90 days is an appropriate time frame. This is due to the following:
1) It takes at least 6 – 8 weeks for the physiology to return back to normal.
2) The ovary needs 60 – 70 days to recruit a new cohort of follicles.
3) It takes a good 6 – 8 weeks to get over and work through the emotional trauma of a failed cycle
Recruitment of primary oocytes in the ovary ( get the follicles to pre-antral stage) is a paracrine function of the ovary and is independent from FSH or LH hormones. It is therefore an ongoing process that is not influenced by external factors like the COC pill etc. I therefore have no idea why clinics “jump” from one cycle to the next.
- Week 18 answers kindly provided by Dr. Stephan Volschenk -