Changing the trigger from one agent to another is highly unlikely to influence the number and quality of the oocytes as all these agents have been scrutinised by doing randomised control trials before releasing the drugs for commercial use on the market. See attachment from the Cochrane Review.
Recombinant versus urinary human chorionic gonadotrophin for ovulation induction in assisted conception
Al-Inany HG, Aboulghar M, Mansour R, Proctor M
Urinary human chorionic gonadotrophin was used for several years to trigger ovulation. Similar man-made drugs, recombinant human chorionic gonadotrophin and recombinant luteinizing hormone, have been developed. This review found there was no difference in pregnancy rates or adverse effects between urinary and recombinant human chorionic gonadotrophins. High dose recombinant LH was associated with lower pregnancy rate and the pharmaceutical company manufacturing the product has withdrawn it for clinical use.
- Week 12 answers kindly provided by Dr. Stephan Volschenk -