Fortunately the “American” era of “embryo glue “has come and gone quickly. We understand today  that whether an embryo will implant or not is based on three factors:

1)       The quality of the endometrium.

2)       The technique and experience of the person doing the embryo transfer.

3)       The quality of the embryo, which is dependent on the quality of the sperm and the quality of the egg.

It is therefore clear then that no amount of “glue” of what ever substance is going to ensure that the embryo implants and lead to a pregnancy.

- Week 31 answers kindly provided by Dr. Stephan Volschenk -

The embryo is generally ready to hatch out of its shell late on day 5 and ready for implantation from day 6 onwards.

- Week 16 answers kindly provided by Dr. Stephan Volschenk -

The biggest factor playing a role during implantation is the quality of the embryo – about 75-80%. The rest is made up of uterine factors, such as the presence of submucosal and large intramural fibroids, adenomyosis etc. and immunological and thrombotic factors such as HLA incompatibility, thrombophylia’s, etc.

- Week 6 answers kindly provided by Dr. Stephan Volschenk -

New literature supports the fact that excessive stimulation is detrimental to the outcome of an IVF cycle from the point of view that it has a negative effect on the endometrial lining from an implantation point of view. According to ISMAAR, a milder approach may lead to a better outcome.