Archive for the ‘embryo transfer’ Category



What is the 3 day vs 5 day transfer dependant on? When and why do you decide to do one over the other?

Sunday, November 9th, 2008

It depends again on where you are doing your ART. Some clinics, especially in Germany, only do day 2 ET’s for example. Some only do day 3 and others day 5 and somewhere in between all of the above, some do day 3 and day 5 transfers depending on the embryology.

- Week 22 answers kindly provided by Dr. Stephan Volschenk -

Due to severe endometriosis my ovaries have been damaged and I do not produce many eggs (4-5) when stimulated. However, fertilasation has occurred in both of our failed ivf’s, first time there was only one embryo to transfer, the second time there were two. Both were day 3 transfers and good quality embryos but both resulted in bfn. If there are no immunological issues at play, would it be advisable to let the embryos grow until day 5 to see if there is a quality issue or should we transfer them again on day three so that they get quicker to their natural environment? I.e, is it possible that if a day 5 embryo degenerates in vitro, it would have possibly survived in vivo?

Sunday, November 9th, 2008

ART is unfortunately not an exact science, and it is therefore difficult to predict whether the embryos will do better being back in the uterus on day 3 or stay in the dish ‘till day 5. Generally, if one has 3 or more good 8 cell embryos on day 3 , one can safely grow them to day 5 without the risk of not having nothing to transfer on day 5. If there are less than 3 good embryos on day 3, it does not really make a difference as to whether you transfer on day 3 .

- Week 22 answers kindly provided by Dr. Stephan Volschenk -

“I’d like to ask the good doctor about (elective) single embryo transfers. Is it only recommended/worthwhile if there is a “perfect” day 5 blastocyst available for transfer? What “grade” should the “perfect” blast be? How much is the success rate affected if the embryo selected for transfer is an “early blastocyst” by day 5 (i.e. not quite a blast but on it’s way to becoming one)? How significant is it if the patient has no “perfect” blastocysts for transfer? Is it unlikely that the embryo selected for transfer will continue to develop and implant? If a patient had 2 “early” blastocysts on day 5 , would you recommend that they rather transfer the 2 knowing that it is unlikely that both will take? As background, the patient would want to avoid the possibility of twins almost completely, while still ensuring a high degree of success for the IVF cycle. The patient has had a normal fullterm pregnancy (resulting in a live baby) before and the only fertility problem is damaged/blocked fallopian tubes.

Sunday, November 9th, 2008

The world is at present ,divided with regards to single or double embryo transfers and is much dependent on where you happen to find yourself in the world when doing ART. The only way however to try and ensure a singleton pregnancy is doing an elective SET.(There is a possibility of 0.8% of a single embryo leading to an identical twin pregnancy)A few factors have to be taken into consideration though, before embarking on an elective SET namely:
1)    Age
2)    Number previous attempts
3)    Reproductive history
4)    Embryo quality on the day of transfer
5)    Successful freezing program of the clinic

It is therefore clear from the above that the decision as to whether or not to do an elective SET is not an easy one as one would aim for the best outcome of being pregnant when presented with all the facts.

- Week 22 answers kindly provided by Dr. Stephan Volschenk -

Is it possible for a Dr to perform an Embryo Transfer without using the sonar as a guide and what are the chances of not transferring the embryo deep enough as there is nothing guiding or showing you the uterus.

Thursday, September 18th, 2008

The jury has been out regarding this issue for a while now, and it is clear that ultrasound guided embryo transfers are more reliable and accurate than blind, fixed distance transfers. There are a few studies that feel otherwise, but the overwhelming evidence support the use of ultrasound during the E.T. The endocervical canal differs from patient to patient and therefore, if you are able to see what you are doing, it will inevitable guarantee that you place the embryos in the endometrial cavity EVERY time. It is also less traumatic to the patient if one can actually see what you are doing.

- Week 21 answers kindly provided by Dr. Stephan Volschenk -

How would the day by day developmental course of a 5 day transfer look like to test date?

Saturday, June 28th, 2008

-1dpt ..embryo is growing and developing
0dpt… Embryo is now a blastocyst
1dpt….Blastocyst hatches out of shell on this day
2dpt.. Blastocyst attaches to a site on the uterine lining
3dpt.. Implantation begins,as the blastocyst begins to bury in the lining
4dpt.. Implantation process continues and morula buries deeper in the lining
5dpt.. Morula is completely inmplanted in the lining and has placenta cells & fetal cells
6dpt…Placenta cells begin to secret HCG in the blood
7dpt…More HCG is produced as fetus develops
8dpt…More HCG is produced as fetus develops
9dpt…HCG levels are now high enough to be immediately detected on HPT

* This excerpt from an unknown source was confirmed to be reasonably correct by Dr.V

- Week 17 answers kindly provided by Dr. Stephan Volschenk -

Would you recommend the use of muscle relaxants before ET, especially if there has been a bit of pain and bleeding after ER, and if so what does he recommend, and how long before ET?

Friday, June 13th, 2008

There is no indication for the administration of muscle relaxants prior to ET. One tries to steer clear of taking any unnecessary medication during this time. The best way to manage this would be acupuncture the day before, and the day of ET .

- Week 16 answers kindly provided by Dr. Stephan Volschenk -

Would it be possible for your lab to show us pictures of good quality embryos and their stages of development duing laboratory incubation?

Sunday, June 1st, 2008

Day 1 Post Fertilisation - Zygote

Day 2 – 4 Cell embryo

Day 3 – 8 Cell Embryo

Day 4 Compacting Embryo

Day 5 Blastocyst

 

- Week 14 answers kindly provided by Dr. Stephan Volschenk -

Added 24 October 2008: See also - http://www.nashvillefertility.com/embryo_development_photo_gallery.htm

 

 

What percentage of embryo fragmentation is acceptable for transfer?

Sunday, April 20th, 2008

Anything below 20% fragmentation.

- Week 11 answers kindly provided by Dr. Stephan Volschenk -

There are many forms of alternative practices (i.e. acupuncture, reflexology, full body massage etc.) Which ones of these do you believe have real efficacy? And if you had to recommend one, which would you recommend, and at which stages of treatment?

Tuesday, April 8th, 2008

Acupuncture is for now the only alternative method of treatment that has been evaluated by using randomised trials and shown to be beneficial around the time of embryo transfer.( Day on and after ET) Therefore it is what I can recommend at this stage in time.

- Week 9 answers kindly provided by Dr. Stephan Volschenk -

A German study showed an increased rate of clinical pregnancies when combining acupuncture with IVF. Do you think it is better for patients to go for acupuncture before treatments to prepare the body or for the patient to jump right in just before or while busy with IVF treatment?

Tuesday, April 8th, 2008

The jury is out with regards to the fact that acupuncture ON the day of embryo transfer and on the day FOLLOWING embryo transfer seem to be beneficial from a pregnancy rate point of view. It is however not clear as to what the benefit might be during the period leading up to IVF or for how long.

- Week 9 answers kindly provided by Dr. Stephan Volschenk -

QUESTION?

You got a good question?
Ask it here >>

CATEGORIES


ARCHIVES